Factors that modulate the placement of primer tRNA3 Lys onto the viral RNA genome in human immunodefi-ciency virus type 1 (HIV-1) were investigated through analysis of reverse-transcribed products that are extend-ed from the tRNA3 Lys primer. Mutations were introduced into the HIV-1 pol gene to result in the appearance of a stop codon in the open reading frame of the reverse transcriptase (RT) gene. These constructs, BH10-RT1 and BH10-RT2, yielded viruses with truncated Pol proteins. Alternatively, we altered the sequences involved in frameshifting by generating the construct BH10-FS. With each of these mutated viruses, we found that the primer tRNA3 Lys that was placed onto viral genomic RNA was present in an unextended state. In contrast,...
AbstractThe primer binding site (PBS) is involved in two stages during the reverse transcription of ...
AbstractSimian immunodeficiency virus (SIV) and human immunodeficiency virus (HIV-1) preferentially ...
<p><b>Copyright information:</b></p><p>Taken from "The availability of the primer activation signal ...
Human immunodeficiency virus type 1 uses the tRNA3Lys molecule as a selective primer for reverse tra...
The human immunodeficiency virus type 1 genomic RNA primer-binding site (PBS) sequence comprises 18 ...
The initiation of human immunodeficiency virus type 1 (HIV-1) reverse transcription occurs by the ex...
The initiation of human immunodeficiency virus type 1 reverse transcription occurs by extension of a...
During HIV-1 assembly, the major mammalian tRNA$ rm sp{Lys}$ isoacceptors, tRNA$ rm sp{Lys1,2}$ and ...
Human immunodeficiency virus type 1 (HIV-1) reverse transcription is primed by the cellular tRNA(3)(...
Reverse transcription of human immunodeficiency virus type-1 (HIV-1) is primed by cellular tRNALys3...
Retroviruses use a specific tRNA, whose 3 ′ end is complementary to the 18 nucleotides of the primer...
AbstractThe initiation of HIV-1 reverse transcription is primed by a cellular tRNALys,3molecule whic...
AbstractHIV-1 virions contain approximately equal amounts of tRNALys,3and tRNALys1,2, yet tRNALys,3h...
Nucleotide segment (1169)AAAA(1172) constitutes an A-rich loop within human immunodeficiency virus t...
AbstractThe initiation of HIV-1 reverse transcription utilizes a cellular tRNALys,3 as a primer. The...
AbstractThe primer binding site (PBS) is involved in two stages during the reverse transcription of ...
AbstractSimian immunodeficiency virus (SIV) and human immunodeficiency virus (HIV-1) preferentially ...
<p><b>Copyright information:</b></p><p>Taken from "The availability of the primer activation signal ...
Human immunodeficiency virus type 1 uses the tRNA3Lys molecule as a selective primer for reverse tra...
The human immunodeficiency virus type 1 genomic RNA primer-binding site (PBS) sequence comprises 18 ...
The initiation of human immunodeficiency virus type 1 (HIV-1) reverse transcription occurs by the ex...
The initiation of human immunodeficiency virus type 1 reverse transcription occurs by extension of a...
During HIV-1 assembly, the major mammalian tRNA$ rm sp{Lys}$ isoacceptors, tRNA$ rm sp{Lys1,2}$ and ...
Human immunodeficiency virus type 1 (HIV-1) reverse transcription is primed by the cellular tRNA(3)(...
Reverse transcription of human immunodeficiency virus type-1 (HIV-1) is primed by cellular tRNALys3...
Retroviruses use a specific tRNA, whose 3 ′ end is complementary to the 18 nucleotides of the primer...
AbstractThe initiation of HIV-1 reverse transcription is primed by a cellular tRNALys,3molecule whic...
AbstractHIV-1 virions contain approximately equal amounts of tRNALys,3and tRNALys1,2, yet tRNALys,3h...
Nucleotide segment (1169)AAAA(1172) constitutes an A-rich loop within human immunodeficiency virus t...
AbstractThe initiation of HIV-1 reverse transcription utilizes a cellular tRNALys,3 as a primer. The...
AbstractThe primer binding site (PBS) is involved in two stages during the reverse transcription of ...
AbstractSimian immunodeficiency virus (SIV) and human immunodeficiency virus (HIV-1) preferentially ...
<p><b>Copyright information:</b></p><p>Taken from "The availability of the primer activation signal ...