Original Research Nephrotoxicity of HighlDose Gadolinium Compared with Iodinated Contrast

To determine if high-dose gadolinium chelntes arc less nephrotorlc than iodinated contrast. Records of 342 patients who had recdved high-dose gadouniUm (.2 to viewed to Idenw patients who had also recdwed io-dinated contrast for radiographic examinations. Their clinical course and laboratory data were reviewed to Identify changer in serum creatinine attributable to the contrast agents. h 84 patients, neerrim creatInlne data were available pre and post both gadounium and iodinated contrast. The mean change in swum creati-nine &er gadolinium in these 64 patients was-.07 mg/dL (-6 pmol/L). By compprlson. the mean change in serum matinine h the game patients after iodi-nated contrast WWI 3 5 mg/dL (+31 pnol/L) from 2.0 f 1.4 to 2.3? 1.8 (P =.oOa). Eleven of the 64 patients had iadfnated contrast-induced renal failure [.S mg/dL or greater rise in mnim creatinine]: none had gadolin-ium contrast-induced renal &rllrue derpite the high gadolinium dose and high prevalence of underlying re-nal imui3ciency. High-d- gadolinium chelates arc sigxMcnntly less nephmtodc than iodinated contrast..4 mmol/Ltgl for majpetic reMInancc imaging were re-Indcr twnw Gadohrum * Angiography lodlne Renal * Kidney- Hyper. tenslo