The Reformulation Regime in Drug Discovery: Revisiting Polyherbals and Property Rights in the Ayurvedic Industry

Abstract In so-called traditional medicine in South Asia, substances have not ordi-narily been prescribed or consumed in isolation, yet the transformations of compound formulations have been comparatively little studied from any position within anthro-pology or history. Since the early twentieth century, ayurvedic formulations have often been redesigned to address the biomedical disorders of a new global clientele. This has involved overlapping medical cultures and the creation of heterodox epis-temologies, which have then allowed the creation of new “traditional ” products that suit the demands of the market. In India, these new formulations fall under the cat-egory of “Ayurvedic Proprietary Medicines, ” which are distinct from classical, tex-tual (shastric) formulations already in the public domain. Proprietary medicines are the object of specific systems of appropriation and protection, which have not only gained central stage in the country but also influenced international regulatory bodies. This article seeks to explore the way in which the “reformulation regime ” has fostered the emergence of alternative models of property rights, and their global acceptance, as well as how, in turn, these new forms of property have today come to drive pharma-ceutical innovation itself. By analyzing this “looping effect, ” this article sets out prospective avenues to study the industrialization of traditional medicine and the complex interface between regulatory systems, innovation processes, and the market