Letters to the Editor

Limb-girdle muscular dystrophy with apparently diVerent clinical courses within sexes in a large inbred kindred EDITOR—The autosomal recessive limb-girdle muscular dystrophies (AR-LGMD) are clinical entities characterised by primary and progressive muscle degeneration, mainly at the pelvic and shoulder girdles, with great variability in the clinical course. Some patients present a severe course simi-lar to Duchenne muscular dystrophy, while others maintain the capacity to walk even in adult life.1–3 At least eight autosomal recessive genes have been mapped. The chromosome localisation of these genes and their products, and a brief comment on the clinical course of each type of AR-LGMD are summarised in table 1. Of these mapped genes, six have been cloned: the gene responsible fo