Correspondence Between Stimulus Encoding- and Maintenance-Related Neural Processes Underlies Successful Working Memory

The ability to actively maintain information in working memory (WM) is vital for goal-directed behavior, but the mechanisms under-lying this process remain elusive. We hypothesized that successful WM relies upon a correspondence between the neural processes associated with stimulus encoding and the neural processes associated with maintenance. Using functional magnetic resonance imaging, we identified regional activity and inter-regional connec-tivity during stimulus encoding and the maintenance of those stimuli when they were no longer present. We compared correspon-dence in these neural processes across encoding and maintenance epochs with WM performance. Critically, greater correspondence between encoding and maintenance in 1) regional activity in the lateral prefrontal cortex (PFC) and 2) connectivity between lateral PFC and extrastriate cortex was associated with increased per-formance. These findings suggest that the conservation of neural processes across encoding and maintenance supports the integrity of representations in WM