Modification by covalent attachment of monomethoxypoly-ethylene glycol (PEG) can reduce the immunogenicity and prolong the circulating life of injected enzymes, making their use as therapeutic agents feasible. We report the first clinical use of PEG-modified Arthrobacter protoformiae uricase (PEG-uricase) to treat hyperuricemia in a patient with non-Hodgkin lymphoma and renal insufficiency who was allergic to allopurinol. Two intramuscular injections totaling 3 U/kg body weight during the first 30 hours of treatment lowered the plasma urate level from 910 to 190 fjtmol/L (15.3 to 3.2 mg/dL), after which a dose of 2 U/kg every 5 to 6 days maintained the plasma urate level at 540 u,mol/L (9 mg/ dL) or lower. After the injection of PEG-uricase...
Full list of author information is available at the end of the articletals in tissues and increases ...
Limitations in efficacy and/or tolerance of currently available urate-lowering therapies (ULTs), suc...
Limitations in efficacy and/or tolerance of currently available urate-lowering therapies (ULTs), suc...
Humans and higher primates are unique in that they lack uricase, the enzyme capable of oxidizing uri...
<div><h3>Background</h3><p>Uricase has proven therapeutic value in treating hyperuricemia but suffic...
Uricase (urate oxidase EC 1.7.3.3, UC) catalyses the oxidation of uric acid, a final product of puri...
Thesis (Master's)--University of Washington, 2020Due to the lack of uricase, humans are not capable ...
PEGylation is a successful strategy for improving the biochemical and biopharmaceutical properties o...
Background: Uricase has proven therapeutic value in treating hyperuricemia but sufficient reduction ...
Hyperuricemia is a feature of several pathologies and requires an appropriate and often early treatm...
Abstract: Covalent attachment of polyethylene glycol (PEG) to active proteins (PEGylation technology...
ABSTRACT Treatment of refractory gout remains a challenge on drug development.While pegloticase, a r...
Abuchowskl, Abraham, Dennis Karp and Frank F. Davis: injection, whereas 1 0 U were effective for les...
Uricase from Bacillus fastidiosus (UC) was covalently linked to linear PEG (PEG-1) (Mw 5 kDa), branc...
BACKGROUND: Hyperuricemia and tumor lysis syndrome (TLS) are serious complications that can occur du...
Full list of author information is available at the end of the articletals in tissues and increases ...
Limitations in efficacy and/or tolerance of currently available urate-lowering therapies (ULTs), suc...
Limitations in efficacy and/or tolerance of currently available urate-lowering therapies (ULTs), suc...
Humans and higher primates are unique in that they lack uricase, the enzyme capable of oxidizing uri...
<div><h3>Background</h3><p>Uricase has proven therapeutic value in treating hyperuricemia but suffic...
Uricase (urate oxidase EC 1.7.3.3, UC) catalyses the oxidation of uric acid, a final product of puri...
Thesis (Master's)--University of Washington, 2020Due to the lack of uricase, humans are not capable ...
PEGylation is a successful strategy for improving the biochemical and biopharmaceutical properties o...
Background: Uricase has proven therapeutic value in treating hyperuricemia but sufficient reduction ...
Hyperuricemia is a feature of several pathologies and requires an appropriate and often early treatm...
Abstract: Covalent attachment of polyethylene glycol (PEG) to active proteins (PEGylation technology...
ABSTRACT Treatment of refractory gout remains a challenge on drug development.While pegloticase, a r...
Abuchowskl, Abraham, Dennis Karp and Frank F. Davis: injection, whereas 1 0 U were effective for les...
Uricase from Bacillus fastidiosus (UC) was covalently linked to linear PEG (PEG-1) (Mw 5 kDa), branc...
BACKGROUND: Hyperuricemia and tumor lysis syndrome (TLS) are serious complications that can occur du...
Full list of author information is available at the end of the articletals in tissues and increases ...
Limitations in efficacy and/or tolerance of currently available urate-lowering therapies (ULTs), suc...
Limitations in efficacy and/or tolerance of currently available urate-lowering therapies (ULTs), suc...