EDITORIAL Spotlight on metabolic remodelling in heart failure

This editorial refers to a collection of nine review articles invited for this special issue on metabolic remodelling in heart failure, guest edited by Torsten Doenst and E. Dale Abel The term ‘remodelling ’ has been abundantly used in the context of heart failure with many different meanings.1 –3 It was originally described in a rat model as the structural and functional response of the remote heart muscle to a local infarct caused by the occlusion of the left anterior descending coronary artery.4 Thereafter, a plethora of experimental and clinical studies have addressed mechan-isms of remodelling and the concept is widely linked to the develop-ment of heart failure.5 However, metabolic aspects of remodelling have until recently been less well investigated. The development of new molecular techniques, including diverse approaches to global analysis of gene expression6,7 and broad-base