Human parvovirus B19 infection causes cell cycle arrest of human erythroid progenitors at late S phase that favors viral DNA replication. J Virol 87: 12766–12775. doi

Human parvovirus B19 (B19V) infection has a unique tropism to human erythroid progenitor cells (EPCs) in human bone mar-row and the fetal liver. It has been reported that both B19V infection and expression of the large nonstructural protein NS1 ar-rested EPCs at a cell cycle status with a 4 N DNA content, which was previously claimed to be “G2/M arrest. ” However, a B19V mutant infectious DNA (M20mTAD2) replicated well in B19V-semipermissive UT7/Epo-S1 cells but did not induce G2/M arrest (S