Chinese Journal of Clinical Oncolgy

OBJECTIVE To Jnvest~gate the relationship between body mass ~ndex (BMI) and tung cancer risk among men in urban Shanghai, China. METHODS Between January 1,1986 and September 30,1989, a total of 18,244 male readents of urban Shanghai were recruited in the prospective cohort study. The eligible study subjects were those aged 45 to 64 years and w~thout history of cancer. Through July 10 ''~, 2003 (17 years follow-up), 467 new cases of lung cancer were identified in the cohort. Cox regression models were used to estimate the adjusted relative risks (RRs) and 95% confidence intervals (CIs). RESULTS The risk of lung cancer decreased with increasing in BMI. After adjustment for some potential confounding factors, a relative risk of 0.6 (highest versus lowest quintile of BMI) was observed (P-trend =0.01). Stratified by smoking status, an inverse association of body mass index with lung cancer risk still existed among current smokers. There were too few cases of tung cancer to draw a valid result among men who never smoked