Open Access JCT Predictability and Management of OARs Toxicity in Patients with Prostate Cancer Treated with High-Dose

Copyright © 2013 Vincenzo Ravo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In accor-dance of the Creative Commons Attribution License all Copyrights © 2013 are reserved for SCIRP and the owner of the intellectual property Vincenzo Ravo et al. All Copyright © 2013 are guarded by law and by SCIRP as a guardian. Aim: To evaluate the predictability of toxicity analyzing the dose-volume histograms (DVHs) and to verify the effec-tiveness of preventive measures limiting side toxicity considering the evolution of the radiation techniques for prostate cancer treatment. Materials and Methods: 208 patients with localized prostate cancer were treated with exclusive ra-diotherapy until 73.8 Gy (group A) or 79.2 Gy (group B) with the dose escalation technique. Preventive measures to minimize the side effects were recommended in group B. Results: The assessment of genitourinary toxicity was similar while gastrointestinal toxicity was better in group B. Valuating the treatment plans, we found that most of the patients developing toxicity had “borderline ” DVHs. Conclusion: Our analysis led to the establishment of a protocol for the management of patients with “border-line ” DVH