Add to ORKGThe p53 tumor suppressor protein is a key regulator of cell cycle and death that is involved in many cell signaling pathways and is tightly regulated in mammalian cells. Post-translational modifications of p53 have been inves-tigated previously mainly using antibodies. In this study, utilizing LC-MS/MS analysis, we have characterized p53 protein from COS-1 cells. Several already known post-translational modifications were observed, such as phos-phorylation on serines 15, 33, 315, and 392 as well a
AbstractRecent studies suggest that acetylation of the p53 tumor suppressor protein is not important...
SummaryAlthough previous studies indicate that loss of p53-mediated cell cycle arrest, apoptosis, an...
The tumor suppressor p53 is a transcriptional regulator whose ability to inhibit cell growth is depe...
The p53 tumor suppressor protein is a key regulator of cell cycle and death that is involved in many...
The p53 tumor suppressor protein is extensively post-translationally modified, mostly by phosphoryla...
La protéine suppresseur de tumeurs p53, est impliquée dans de nombreuses voies de signalisation cell...
Post-translational modifications serve as important regulatory elements in modulating the transcript...
Post-translational modifications of p53 are critical in modulating its tumor suppressive functions. ...
grantor: University of Torontop53, the tumour suppressor, has potent growth suppressive fu...
This is an open-access article distributed under the terms of the Creative Commons Attribution Licen...
p53 is the most commonly mutated tumor suppressor gene in human cancers. Activation of p53 maintains...
Post-translational modifications, such as phosphorylation and acetylation of the tumour suppressor p...
The activity of the p53 gene product is regulated by a plethora of posttranslational modifications. ...
The tumor suppressor p53 is a transcription factor that regulates the expression of dozens of target...
SummaryThe activation of the tumor suppressor p53 facilitates the cellular response to genotoxic str...
AbstractRecent studies suggest that acetylation of the p53 tumor suppressor protein is not important...
SummaryAlthough previous studies indicate that loss of p53-mediated cell cycle arrest, apoptosis, an...
The tumor suppressor p53 is a transcriptional regulator whose ability to inhibit cell growth is depe...
The p53 tumor suppressor protein is a key regulator of cell cycle and death that is involved in many...
The p53 tumor suppressor protein is extensively post-translationally modified, mostly by phosphoryla...
La protéine suppresseur de tumeurs p53, est impliquée dans de nombreuses voies de signalisation cell...
Post-translational modifications serve as important regulatory elements in modulating the transcript...
Post-translational modifications of p53 are critical in modulating its tumor suppressive functions. ...
grantor: University of Torontop53, the tumour suppressor, has potent growth suppressive fu...
This is an open-access article distributed under the terms of the Creative Commons Attribution Licen...
p53 is the most commonly mutated tumor suppressor gene in human cancers. Activation of p53 maintains...
Post-translational modifications, such as phosphorylation and acetylation of the tumour suppressor p...
The activity of the p53 gene product is regulated by a plethora of posttranslational modifications. ...
The tumor suppressor p53 is a transcription factor that regulates the expression of dozens of target...
SummaryThe activation of the tumor suppressor p53 facilitates the cellular response to genotoxic str...
AbstractRecent studies suggest that acetylation of the p53 tumor suppressor protein is not important...
SummaryAlthough previous studies indicate that loss of p53-mediated cell cycle arrest, apoptosis, an...
The tumor suppressor p53 is a transcriptional regulator whose ability to inhibit cell growth is depe...