Add to ORKGbleeding occurs less frequently than expected. Molho et al1 showed that 9 % of the young adult patients with severe hemophilia did not bleed into joints. The exact mechanism underlying this vari-ability in bleeding pattern is not completely under-stood. Several mechanisms have been proposed to explain this discrepancy, including coinheritance of some prothrombotic genetic mutations, impaired fibrinolysis, and elevated endogenous thrombin gen-eration.2-4 Of those, the prothrombotic mutations have drawn much attention. Factor V Leiden (FVL) and the factor II mutations are two of the most fre-quent genetic risk factors leading to venous throm-bosis by causing activated protein C resistance and increased levels of plasma prothrombin, respective...
Background: Resistance to activated protein C due to the factor V R506Q (Leiden) mutation is the mos...
contrast to the well-established role in the context of venous thrombotic events, the impact of both...
Under physiologic conditions, a hemostatic balance is achieved through the effects of natural procoa...
Several inherited prothrombotic risk factors have been identified so far. Among them, the factor V (...
There is considerable variability in bleeding patterns of severe haemophilia (<1% factorVIII). Knowl...
There is considerable variability in bleeding patterns of severe haemophilia (<1% factor VIII). Know...
The Impact of Prothrombotic Mutations on Factor Consumption in Adult Patients With Sever
Purpose: Although a good correlation usually exists between the clinical severity of the disease and...
Venous thromboembolism constitutes a major medical problem afflicting millions of individuals worldw...
People with hemophilia (PWH) have an increased tendency to bleed, often into their joints, causing d...
It is well known that the clinical phenotype of hemophilia may vary greatly among patients with the ...
The basis for 10-15% of patients with severe haemophilia having clinically mild disease is not fully...
Patients with severe haemophilia have a plasma activity level of factor VIII or IX below 1%. Althoug...
Abstract—Risk factors for venous thrombosis in adults are the prothrombin G20210A and the factor V (...
A b s t r a c t The clinical phenotype in hemophilia generally correlates with the type of mutations...
Background: Resistance to activated protein C due to the factor V R506Q (Leiden) mutation is the mos...
contrast to the well-established role in the context of venous thrombotic events, the impact of both...
Under physiologic conditions, a hemostatic balance is achieved through the effects of natural procoa...
Several inherited prothrombotic risk factors have been identified so far. Among them, the factor V (...
There is considerable variability in bleeding patterns of severe haemophilia (<1% factorVIII). Knowl...
There is considerable variability in bleeding patterns of severe haemophilia (<1% factor VIII). Know...
The Impact of Prothrombotic Mutations on Factor Consumption in Adult Patients With Sever
Purpose: Although a good correlation usually exists between the clinical severity of the disease and...
Venous thromboembolism constitutes a major medical problem afflicting millions of individuals worldw...
People with hemophilia (PWH) have an increased tendency to bleed, often into their joints, causing d...
It is well known that the clinical phenotype of hemophilia may vary greatly among patients with the ...
The basis for 10-15% of patients with severe haemophilia having clinically mild disease is not fully...
Patients with severe haemophilia have a plasma activity level of factor VIII or IX below 1%. Althoug...
Abstract—Risk factors for venous thrombosis in adults are the prothrombin G20210A and the factor V (...
A b s t r a c t The clinical phenotype in hemophilia generally correlates with the type of mutations...
Background: Resistance to activated protein C due to the factor V R506Q (Leiden) mutation is the mos...
contrast to the well-established role in the context of venous thrombotic events, the impact of both...
Under physiologic conditions, a hemostatic balance is achieved through the effects of natural procoa...