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The study presented attempts to prove the concept that mechanical changes in the structure of a bone can be predicted for a specific exercise by a subject specific model created from CT data, MRI data, EMG data, and a physiologic FE model. Previous work generated a subject specific FE model of a femur via CT and MRI data as well as created a set of subject specific biomechanical muscle forces that are required to perform a single leg extension exercise. The FE model and muscle forces were implemented into a single leg extension FE code (ABAQUS) along with a specialized bone remodeling UMAT. The UMAT updated the mechanical properties of the femur via a damage-repair bone remodeling algorithm. The single leg extension FE code was verified by applying walking loads to the femur and allowing the system to equilibrate. The results were used to apply the appropriate walking loads to the final FE simulation for the single leg extension exercise. The final FE simulation included applying the single leg extension loads over a one year period and plotting the change in porosity at various regions of the femoral neck. Although only two regions were found to generate valid results, the data seemed counterintuitive to Wolff’s Law which states that bone adaptation is promoted whe