Down Syndrome and Congenital Heart Disease:

most frequent chromosomal aberration associated with mild to moderate mental disability, a characteristic facial appearance, and poor muscle tone in infancy.1 The incidence of DS in live births is approximately 1 in 733, however this rate varies according to the mother´s age; in mothers 45 years of age or older, the incidence reaches one in every 30 live births. After mother 35 years, the risk of conceiving a child with DS increases significantly, however younger women though having a lower risk represent half of all mothers with babies with DS because of their higher overall birth rate.2 The risk of recurrence is 1 % in the general population.3 Children with DS have typical physical phenotype of menta