Anti-infl ammatory activity of Anthemis aciphylla var. aciphylla Boiss.

Abstract: Ethanolic (EEAA) and sesquiterpene lactone (SEAA) extracts of the aerial parts of Anthemis aciphylla var. aciphylla Boiss. (Asteraceae) were evaluated for anti-infl ammatory activity on carrageenin-induced paw edema (acute model) and cotton pellet-induced granuloma (chronic model) in rats. In carrageenin-induced paw edema, EEAA and SEAA at intraperitoneal doses of 50, 100, and 200 mg/kg dose-dependently inhibited the paw edema. In cotton pellet-induced granuloma, the oral administration of EEAA and SEAA at 50, 100, and 200 mg/kg dosages was also found to signifi cantly inhibit granuloma tissue formation. Key words: Anthemis aciphylla, anti-infl ammatory activity, carrageenin, paw edema, cotton pellet Anthemis aciphylla var. aciphylla Boiss.’in antienfl amatuvar aktivites