TRANSPLANTATION Brief report Long-term outcome of patients given transplants of mobilized blood or bone marrow: a report from the International Bone Marrow Transplant Registry and the

We previously compared outcomes after allogeneicperipheral-bloodstemcell (PBSC) and bone marrow (BM) transplantation in 706 patients with leukemia. We obtained long-term follow up on 413 of 491 patients who were alive at the time of the initial report: 141 PBSC and 272 BM recipients. Chronic graft-versus-host disease (GVHD) was more frequent after PBSC compared to BM transplantation (RR 1.65, P<.001) yet relapse rates were similar in both groups. Leukemia-free survival rates were higher after PBSC than BM transplantation for pa-tients with advanced chronic myeloid leuke-mia (33 % versus 25%) but lower for those in first chronic phase (41 % versus 61%) due to higher rates of late transplant-related mortal-ity. Leukemia-free survival was similar after PBSC and BM transplantation for acute leu-kemia. These data represent the early expe-rience with PBSC grafts. Long-term out-comes in recipients of more recent transplants are required to better evaluate the role of PBSC grafts relative to BM trans-plantation. (Blood. 2006;108:4288-4290) © 2006 by The American Society of Hematolog