FORUM Current and Future Application of Genetic Toxicity Assays: The Role and Value of In Vitro Mammalian Assays

With the advent of new technologies (e.g., genomics, automated analyses, and in vivo monitoring), new regulations (e.g., the reduction of animal tests by the European REACH), and new approaches to toxicology (e.g., Toxicity Testing in the 21st Century, National Research Council), the field of regulatory genetic toxicology is undergoing a serious re-examination. Within this context, Toxicological Sciences has published a series of articles in its Forum Section on the theme, ‘‘Genetic Toxicity Assessment: Employing the Best Science for Human Safety Evaluation’ ’ (beginning with Goodman et al.). As a contribution to the Forum discussions, we present current methods fo