Decrease in Circulating Concentrations of Soluble Receptors for Advanced Glycation End Products at the Time of

Dietary advanced glycation end products (AGEs) and their interactions with the receptor for AGEs (RAGE) may play a role in the pathogenesis of type 1 diabetes. This study set out to assess whether there is any association between circulating concentrations of soluble RAGE (sRAGE), AGEs, and their ratio with the appear-ance of diabetes-associated autoantibodies in children progressing to clinical diabetes. RESEARCH DESIGN AND METHODS Serum concentrations of sRAGE,N-«(carboxymethyl)lysine (CML) adducts and the sRAGE/CML ratio were analyzed in children who progressed to type 1 diabetes. The samples were taken at four time points: before seroconversion, at the time of the first autoantibody-positive sample, at the time of the first sample positive for multiple (>2) autoantibodies, and close to the disease diagnosis. Samples of autoantibody-negative controlsmatched for age, sex, and HLA-conferred diabetes risk were analyzed at corresponding time points. RESULT