Activation of peroxisome proliferator-activated receptor- by rosiglitazone improves lipid homeostasis at the adipose tissue-liver axis in ethanol-fed mice

tor- by rosiglitazone improves lipid homeostasis at the adipose tissue-liver axis in ethanol-fed mice. Am J Physiol Gastrointest Liver Physiol 302: G548–G557, 2012. First published December 15, 2012; doi:10.1152/ajpgi.00342.2011.—The development of alcohol-induced fatty liver is associated with a reduction of white adipose tissue (WAT). Peroxisome proliferator-activated receptor (PPAR)- promi-nently distributes in the WAT and plays a crucial role in maintaining adiposity. The present study investigated the effects of PPAR- activation by rosiglitazone on lipid homeostasis at the adipose tissue-liver axis. Adult C57BL/6 male mice were pair fed liquid diet containing ethanol or isocaloric maltose dextrin for 8 wk with or without rosiglitazone supplementation to ethanol-fed mice for the last 3 wk. Ethanol exposure downregulated adipose PPAR- gene and reduced the WAT mass in association with induction of inflammation, which was attenuated by rosiglitazone. Ethanol exposure stimulate