British Journal of Rheumatology 1985:24(suppl 1): 122—127 EFFECTS OF PURIFIED HUMAN INTERLEUKIN-1 ON THE RELEASE OF PROSTAGLANDIN E2 FROM FIBROBLASTS

Human foreskin fibroblasts incubated with purfied human intcrleukin-1 (IL-1) start to release prostaglandin E, (PGE:) 4 h after stimulation and continue to do so for at least 24 h. In addition, anisomycin, an inhibitor of mRNA translation, decreases the stimulator) ' effects of IL-1 indicating that IL-1 induces PGE, production by first activating protein synthesis The relationship of IL-1 to mononuclearccll factor and the role that IL-1 and PGE, may play in the inflammatory processes of rheumatoid arthritis are discussed. KEY WORDS. Intcrleukin-1. Prostaglandin. Rheumatoid arthriti