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Impact of ventilatory modes on the breathing variability in mechanically ventilated infants BAUDIN, Florent, et al. Reduction of breathing variability is associated with adverse outcome. During mechanical ventilation, the variability of ventilatory pressure is dependent on the ventilatory mode. During neurally adjusted ventilatory assist (NAVA), the support is proportional to electrical activity of the diaphragm (EAdi), which reflects the respiratory center output. The variability of EAdi is, therefore, translated into a similar variability in pressures. Contrastingly, conventional ventilatory modes deliver less variable pressures. The impact of the mode on the patient's own respiratory drive is less clear. This study aims to compare the impact of NAVA, pressure-controlled ventilation (PCV), and pressure support ventilation (PSV) on the respiratory drive patterns in infants. We hypothesized that on NAVA, EAdi variability resembles most of the endogenous respiratory drive pattern seen in a control group. BAUDIN, Florent, et al. Impact of ventilatory modes on the breathing variability in mechanically ventilated infants. Frontiers in Pediatrics, 2014, vol. 2, p. 132 DOI: 10.3389/fped.2014.00132 PMID: 2550577