As the popu...

Radiation therapy is a key weapon in the modern arsenal of cancer treatment. However, this effec-tive treatment comes with risks of its own, and the sheer number of patients that undergo radia-tion as a part of their therapy regimen is only increasing. As this number increases, so does the in-cidence of secondary, radiation-induced neoplasias, creating a need for therapeutic agents tar-geted specifically towards reduction in the incidence of and treatment of these cancers. Develop-ment and efficacy testing of these agents requires not only extensive in vitro testing, but also a set of reliable animal models to accurately recreate the complex situations of radiation-induced car-cinogenesis. The laboratory mouse Mus musculus remains the most relevant animal model in can-cer research due to the molecular and physiological similarities it shares with man, its small size and high rate of breeding in captivity, and its fully sequenced genome. In this work, we review re-levant M. musculus inbred and F1 hybrid animal models, as well as methods of induction of radia