A Short Synthesis of a Chiral Alcohol as a New Chiral Auxiliary for Asymmetric Reactions

Asymmetric synthesis has emerged as one of the most rap-idly developing research areas in organic chemistry.1 Among various strategies involved in the asymmetric synthesis, use of chiral auxiliaries and chiral ligands has been extensively studied and a number of new auxiliaries and ligands have been successfully utilized for efficient asymmetric synthe-sis.2 Most of such chiral auxiliaries and ligands have been derived from chiral pools of naturally occurring compounds such as amino acids,2,3 terpenes,2 and carbohydrates.2,4 Thus design of such auxiliaries and ligands have been largely dependent upon the availability of the chiral starting materi-als from natural sources. In this connection, we have initi-ated a research effort towards the development of novel chiral auxiliaries and ligands based upon highly efficient and reliable asymmetric transformations such as asymmetri