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No sponsorships or competing interests have been disclosed for this article. Objective. To evaluate the oncologic and functional outcomes of partial laryngeal surgery (PLS) using transoral laser micro-surgery (TLM) and supracricoid laryngectomy (SCL) in patients with intermediate-stage laryngeal squamous cell car-cinoma (LSCC). Study Design. Historical cohort study. Setting. Single tertiary care center. Subjects and Methods. Retrospective review of oncologic and functional outcomes in intermediate-stage (T2-3/N0-1, stage II and III) LSCC patients who underwent TLM or SCL from 1998 to 2010. Results. Sixty patients were included, of whom 28 (47%) underwent TLM and 32 (53%) underwent SCL. For the entire cohort, 2- and 5-year probabilities were 86.2 % (95% confidence interval [CI], 73.0%-93.2%) and 72.9 % (95 % CI, 52.4%-85.6%), respectively, for overall survival (OS) and 79.3 % (95 % CI, 65.6%-88.0%) and 62.4 % (95 % CI, 41.9%-77.4%), respectively, for recurrence-free survival (RFS). There was no difference between the TLM and SCL cohorts in OS (P =.542) or RFS (P =.483). More than 75 % of patients avoided adjuvant therapy. Communication Scale and Functional Outcome Swallowing Scale scores at median follow-up of 33 months were 2 or better in 97 % and 91 % of patients, respectively, reflecting functional voice and swal-lowing postoperatively. Eighty-eight percent of patients retained a functional larynx. Conclusion. PLS provides excellent oncologic and functional outcomes for intermediate-stage LSCC and should be con-sidered an alternative to chemoradiation or total laryngect-omy in selected patients. Keywords laryngeal cancer, transoral laser microsurgery, supracricoid laryngectom