Intestinal response to growth factors administered alone or in combination with human [Gly2]glucagon-like peptide 2

L. Brubaker. Intestinal response to growth factors adminis-tered alone or in combination with human [Gly2]glucagon-like peptide 2. Am. J. Physiol. 273 (Gastrointest. Liver Physiol. 36): G1252–G1262, 1997.—The control of intestinal epithelial growth is regulated by interactions of growth factors in various cellular compartments of the small and large bowel. Little information is available on the intestinal growth response to combinations of growth factors. We stud-ied the intestinotrophic properties of a dipeptidyl peptidase IV resistant glucagon-like peptide 2 (GLP-2) analog, human [Gly2]GLP-2 (h[Gly2]GLP-2), as well as of epidermal growth factor (EGF), long [Arg3]insulin-like growth factor I (LR3IGF-I), [Gly1]IGF-II, and human growth hormone (hGH), adminis-tered by subcutaneous injection alone or in combination in mice. At the doses tested, h[Gly2]GLP-2 was the most poten