OBJECTIVE — In advanced -cell failure, counterregulatory glucagon responses may be impaired due to a reduced decrement in insulin secretion during the development of hypogly-cemia. The present studies were therefore undertaken to test the hypothesis that these may be improved by increasing this decrement in insulin secretion. RESEARCH DESIGN AND METHODS — Twelve subjects with type 2 diabetes who have been insulin requiring were studied as a model of advanced -cell failure. Glucagon responses were examined during a 90-min hypoglycemic clamp (2.8 mmol/l) on two separate occasions. On one occasion, tolbutamide was infused for 2 h before the clamp so that the decrement in insulin secretion during the induction of hypoglycemia would be increased...
OBJECTIVES: To evaluate the influence of residual beta-cell function on glucagon secretion and gluco...
OBJECTIVE—The physiology of counterregulatory responses during hypoglycemia in intensively treated t...
The aim of this study was to investigate the role of plasma glucagon levels on the blood glucose res...
Rates of hypoglycaemia in those with Type 2 diabetes newly started on insulin are less than in Type ...
OBJECTIVE—Insulin secretion is often diminished in hyperglycemic patients with type 2 diabetes. We e...
The ability of Type 2 diabetic patients to suppress islet B-cell secretion in response to falling pl...
peer reviewedAIMS: To investigate the hyperglycemic and insulinemic response to repeated glucagon in...
Type 2 diabetes (T2D) is characterized by insulin resistance and pancreatic b-cell dysfunction, the ...
Hypoglycaernia is the main limiting factor reaching normo-glycaemia in type I diabetic patients. The...
Iatrogenic hypoglycemia is a major limiting factor inthe strict glycemic management of diabetes (1,2...
Type 2 diabetes is a disease characterized by impaired insulin secretion and defective glucagon supp...
Chronic hyperglycemia impairs insulin action, resulting in glucotoxicity, which can be ameliorated i...
A major, yet poorly understood, feature of type 2 diabetes is the excessive hepatic glucose producti...
Individuals with type 1 diabetes have an impaired glucagon counterregulatory response to hypoglycemi...
Aim: Stepwise intensification of insulin treatment to match the progressive decline of endogenous in...
OBJECTIVES: To evaluate the influence of residual beta-cell function on glucagon secretion and gluco...
OBJECTIVE—The physiology of counterregulatory responses during hypoglycemia in intensively treated t...
The aim of this study was to investigate the role of plasma glucagon levels on the blood glucose res...
Rates of hypoglycaemia in those with Type 2 diabetes newly started on insulin are less than in Type ...
OBJECTIVE—Insulin secretion is often diminished in hyperglycemic patients with type 2 diabetes. We e...
The ability of Type 2 diabetic patients to suppress islet B-cell secretion in response to falling pl...
peer reviewedAIMS: To investigate the hyperglycemic and insulinemic response to repeated glucagon in...
Type 2 diabetes (T2D) is characterized by insulin resistance and pancreatic b-cell dysfunction, the ...
Hypoglycaernia is the main limiting factor reaching normo-glycaemia in type I diabetic patients. The...
Iatrogenic hypoglycemia is a major limiting factor inthe strict glycemic management of diabetes (1,2...
Type 2 diabetes is a disease characterized by impaired insulin secretion and defective glucagon supp...
Chronic hyperglycemia impairs insulin action, resulting in glucotoxicity, which can be ameliorated i...
A major, yet poorly understood, feature of type 2 diabetes is the excessive hepatic glucose producti...
Individuals with type 1 diabetes have an impaired glucagon counterregulatory response to hypoglycemi...
Aim: Stepwise intensification of insulin treatment to match the progressive decline of endogenous in...
OBJECTIVES: To evaluate the influence of residual beta-cell function on glucagon secretion and gluco...
OBJECTIVE—The physiology of counterregulatory responses during hypoglycemia in intensively treated t...
The aim of this study was to investigate the role of plasma glucagon levels on the blood glucose res...