Curr Urol 2013;7:24–27 DOI: 10.1159/000343548 Key Words Abstract

Accessible online at: www.karger.com/cur Radical prostatectomy • Prostate cancer • Transrectal ultrasound biopsy Aims: To evaluate whether the number of biopsies per-formed via transrectal ultrasound (TRUS) accurately predicts pathological parameters such as Gleason sum, prostatic in-traepithelial neoplasia and perineural invasion of the final prostatectomy specimen. Materials and Methods: The co-hort consisted of 99 patients whom had undergone radical prostatectomy. Comparisons were made between the num-ber of biopsies utilised and the presence of the pathological parameters from tissue at time of diagnosis and tissue from the final prostatectomy. Results: A significant difference was noted between Gleason sum, prostatic intraepithelial neoplasia and perineural invasion from tissue at time of di-agnosis irrespective of the number of biopsies utilised and tissue from the radical specimen (p < 0.001, p < 0.001, p < 0.001 respectively). No difference was noted in the mean Gleason sum when 11–14 biopsies were utilised at TRUS and the Gleason sum from the radical specimen. Conclusion: We have demonstrated that the number of biopsies utilised at time of TRUS for diagnosis predicts the accuracy of patho-logical parameters in the final radical prostatectomy speci-men. We believe that 11–14 biopsies should be utilised at time of TRUS as this allows a higher accuracy in the Gleason sum and therefore allows optimum treatment plans to be devised