Ketone Hydrosilylation with Sugar Silanes Followed by Intramolecular Aglycone Delivery: An Orthogonal Glycosylation Strategy

All reagents were used as received unless otherwise noted. Solvents were purified under nitrogen using a solvent purification system (Innovative Technology, inc., Model # SPS-400-3 and PS-400-3). Ni(COD)2 (Strem Chemicals, Inc., used as received), CuCl (Sigma-Aldrich, used as received), 1,3-dimesitylimidazolium chloride (IMes·HCl) 1 were stored and weighed in an inert atmosphere glovebox. Ti(O-i-Pr)4 and Me2Si(H)Cl were distilled and stored under inert atmosphere in Schlenk flasks. All nickel reactions were conducted in flame-dried glassware under a nitrogen atmosphere. 1 H an