The differentiation of naive T-helper (Th) cells into cytokine-secreting effector Th cells requires exposure to multiple signals, including exogenous cytokines. Interleukin-4 (IL-4) plays a major role in this process by promoting the differen-tiation of IL-4–secreting Th2 cells. In Th2 cells, IL-4 gene expression is tightly controlled at the level of transcription by the coordinated binding of multiple transcription factors to regulatory elements in the proximal promoter region. Nuclear factor of activated T cell (NFAT) family members play a critical role in regulating IL-4 transcription and interact with up to five sequences (termed P0 through P4) in the IL-4 promoter. The molecular mechanisms by which IL-4 induces expression of the IL-4 g...
International audienceStat (signal transducers and activators of transcription) and Jak (Janus kinas...
Interleukin-4 (IL-4) modulates the survival, proliferation, and differentiation of a variety of hema...
Interleukin-10 (IL-10), like IL-4, is known to inhibit cytokine expression in activated human monocy...
Interleukin (IL)-4 is an immunomodulatory cytokine produced by a number of cell types including T ce...
SummaryDissecting the molecular mechanisms by which T helper (Th) cells differentiate to effector Th...
Signal transducer and activator of transcription 6 (Stat6) and NF-kappaB are widely distributed tran...
STAT6 plays an important role in IL-4-mediated B cell acti-vation and differentiation. To identify p...
SummaryDissecting the molecular mechanisms by which T helper (Th) cells differentiate to effector Th...
STAT4, which plays a pivotal role in Th1 immune responses, enhances IFN-gamma transcription in respo...
STAT4, which plays a pivotal role in Th1 immune responses, enhances IFN-gamma transcription in respo...
Interleukin-4 (IL-4) is a type I cytokine which acts on multiple hemopoietic cells to promote an an...
AbstractInterleukin-4 (IL-4) stimulation of cells leads to the activation of multiple signaling path...
Stat6 transcription factor is a critical mediator of IL-4-specific gene responses. Tyrosine phosphor...
STAT6 transcription factor, which has been implicated in commitment to Th2, is known to be activated...
International audienceStat (signal transducers and activators of transcription) and Jak (Janus kinas...
International audienceStat (signal transducers and activators of transcription) and Jak (Janus kinas...
Interleukin-4 (IL-4) modulates the survival, proliferation, and differentiation of a variety of hema...
Interleukin-10 (IL-10), like IL-4, is known to inhibit cytokine expression in activated human monocy...
Interleukin (IL)-4 is an immunomodulatory cytokine produced by a number of cell types including T ce...
SummaryDissecting the molecular mechanisms by which T helper (Th) cells differentiate to effector Th...
Signal transducer and activator of transcription 6 (Stat6) and NF-kappaB are widely distributed tran...
STAT6 plays an important role in IL-4-mediated B cell acti-vation and differentiation. To identify p...
SummaryDissecting the molecular mechanisms by which T helper (Th) cells differentiate to effector Th...
STAT4, which plays a pivotal role in Th1 immune responses, enhances IFN-gamma transcription in respo...
STAT4, which plays a pivotal role in Th1 immune responses, enhances IFN-gamma transcription in respo...
Interleukin-4 (IL-4) is a type I cytokine which acts on multiple hemopoietic cells to promote an an...
AbstractInterleukin-4 (IL-4) stimulation of cells leads to the activation of multiple signaling path...
Stat6 transcription factor is a critical mediator of IL-4-specific gene responses. Tyrosine phosphor...
STAT6 transcription factor, which has been implicated in commitment to Th2, is known to be activated...
International audienceStat (signal transducers and activators of transcription) and Jak (Janus kinas...
International audienceStat (signal transducers and activators of transcription) and Jak (Janus kinas...
Interleukin-4 (IL-4) modulates the survival, proliferation, and differentiation of a variety of hema...
Interleukin-10 (IL-10), like IL-4, is known to inhibit cytokine expression in activated human monocy...