Germline CDKN2A mutations are observed in 20–50 % of melanoma-prone families. We identified melanoma patients that were heterozygous for non-coding germline variants in the 50-UTR of CDKN2A (c.-21C> T; c.-25C> T&c.-180G> A; c.-56G> T; c.-67G> C) and examined their impact on the p16INK4a 50-UTR activity using two luciferase-based reporter vectors that differ in basal transcription level and that were transfected into the melanoma-derived WM266-4 and in the breast cancer-derived MCF7 cells. The wild-type 50-UTR sequence, containing a reported SNP (c.-33G> C) and a known melanoma-predisposing mutation (c.-34G> T), was included as controls. Results revealed that the variants at-21 and-34 severely reduced the reporter ac...
Approximately 50 % of all melanoma families worldwide show linkage to 9p21-22, but only about half o...
BACKGROUND: : Inherited mutations in the CDKN2A tumor suppressor gene, which encodes the p16(INK4a) ...
The last three authors equally contributed to the study and are listed in alphabetical order *Corres...
Germline CDKN2A mutations are observed in 20-50% of melanoma-prone families. We identified melanoma ...
Many variants of uncertain functional significance in cancer susceptibility genes lie in regulatory ...
Cyclin-dependent kinase inhibitor type 2A (CDKN2A) has been identified as a major melanoma susceptib...
Cyclin-dependent kinase inhibitor type 2A (CDKN2A) has been identified as a major melanoma susceptib...
Cyclin-dependent kinase inhibitor type 2A (CDKN2A) has been identified as a major melanoma susceptib...
Cyclin-dependent kinase inhibitor type 2A (CDKN2A) has been identified as a major melanoma susceptib...
The CDKN2A gene maps to chromosome 9p21-22 and is responsible for melanoma susceptibility in some fa...
Approximately 50% of all melanoma families worldwide show linkage to 9p21-22, but only about half of...
Background: Inherited mutations in the CDKN2A tumor suppressor gene, which encodes the p16INK4a prot...
Germline mutations within the cyclin-dependent kinase inhibitor 2A (CDKN2A) gene and one of its targ...
Germline mutations in CDKN2A and/or red hair color variants in MC1R genes are associated with an inc...
Approximately 50% of all melanoma families worldwide show linkage to 9p21–22; however, only about ha...
Approximately 50 % of all melanoma families worldwide show linkage to 9p21-22, but only about half o...
BACKGROUND: : Inherited mutations in the CDKN2A tumor suppressor gene, which encodes the p16(INK4a) ...
The last three authors equally contributed to the study and are listed in alphabetical order *Corres...
Germline CDKN2A mutations are observed in 20-50% of melanoma-prone families. We identified melanoma ...
Many variants of uncertain functional significance in cancer susceptibility genes lie in regulatory ...
Cyclin-dependent kinase inhibitor type 2A (CDKN2A) has been identified as a major melanoma susceptib...
Cyclin-dependent kinase inhibitor type 2A (CDKN2A) has been identified as a major melanoma susceptib...
Cyclin-dependent kinase inhibitor type 2A (CDKN2A) has been identified as a major melanoma susceptib...
Cyclin-dependent kinase inhibitor type 2A (CDKN2A) has been identified as a major melanoma susceptib...
The CDKN2A gene maps to chromosome 9p21-22 and is responsible for melanoma susceptibility in some fa...
Approximately 50% of all melanoma families worldwide show linkage to 9p21-22, but only about half of...
Background: Inherited mutations in the CDKN2A tumor suppressor gene, which encodes the p16INK4a prot...
Germline mutations within the cyclin-dependent kinase inhibitor 2A (CDKN2A) gene and one of its targ...
Germline mutations in CDKN2A and/or red hair color variants in MC1R genes are associated with an inc...
Approximately 50% of all melanoma families worldwide show linkage to 9p21–22; however, only about ha...
Approximately 50 % of all melanoma families worldwide show linkage to 9p21-22, but only about half o...
BACKGROUND: : Inherited mutations in the CDKN2A tumor suppressor gene, which encodes the p16(INK4a) ...
The last three authors equally contributed to the study and are listed in alphabetical order *Corres...