Editorial: MMP28 and macrophage polarization: orchestrating the attack of the mac

Macrophages play an importantand complex role in themaintenance of tissue homeo-stasis. These cells are remarkably hetero-geneous, and in response to cues pres-ent in the local microenvironment, they adopt a wide variety of functions to or-chestrate such processes as antimicro-bial defense and pathogen killing, regu-lation of tumorigenesis, allergic inflam-mation, autoimmunity, atherosclerosis, and fibrosis [1]. In an attempt to recon-cile the diverse and at time-disparate roles that macrophages might play in infection, inflammation, and remodel-ing, a nomenclature has been proposed similar to the Th1/Th2 dichotomy, wit