Add to ORKGA very short and concise synthetic route for a novel acyclic version of d4T is described. The required quaternary carbon was successfully installed using a [3,3]-sigmatropic rearrangement. The condensation of the mesylates 16-18 with an adenine base under standard nucleophilic substitution conditions (K2CO3, 18-Crown-6, DMF) in addition to deblocking afforded the target acyclic nucleosides 22-24. In addition, the antiviral evaluations against various viruses were performed. Key Words: Acyclic nucleosides, [3,3]-Sigmatropic rearrangement, Antiviral agent
Following our findings on the anti-human immunodeficiency virus (HIV) activity of acyclovir (ACV) ph...
Upon reacting 3',4'-unsaturated cytosine (8 and 9) and adenine nucleosides (13 and 14) with XeF2/BF3...
A new adenine derivative is prepared through the chemistry of nitrosocarbonyl intermediates. The sy...
Acyclic, achiral nucleoside derivatives 1b-e of adenine, cytosine, 5-methylcytosine, and guanine, co...
Optically pure acyclic nucleoside analogues with a 3(S),5-dihydroxypentyl or 4(R)-methoxy-3(S),5-dih...
The stereoselective synthesis 4′,6′-dually branched carbocyclic nucleosides was accomplished in this...
Novel 1',4'-dimethyl branched carbocyclic nucleosides were synthesized from acetol. The 4&...
with the aim to expand the repertoire of bioactive cyclohexenyl nucleosides, we have herein explored...
Novel methodology for the synthesis of 3\u27-deoxy- and 2\u27 ,3\u27-dideoxy-4\u27 -C-alkyl nucleosi...
A series of doubly flexible nucleoside analogues were designed based on the acyclic sugar scaffold o...
A series of the novel pyrimidine (3-6) and purine (12-15, 18-21) acyclic nucleoside analogues in whi...
Les analogues synthétiques des nucléosides naturels constituant des acides nucléiques occupent une p...
Acyclic nucleosides have been of considerable interest since the approval of aciclovir by the FDA to...
β-Thymidine is a key intermediate in the manufacturing of anti-AIDS agents- AZT and d4 T. A practica...
We describe the synthesis of a variety of lipophilic isosteres of nucleoside triphosphates as potent...
Following our findings on the anti-human immunodeficiency virus (HIV) activity of acyclovir (ACV) ph...
Upon reacting 3',4'-unsaturated cytosine (8 and 9) and adenine nucleosides (13 and 14) with XeF2/BF3...
A new adenine derivative is prepared through the chemistry of nitrosocarbonyl intermediates. The sy...
Acyclic, achiral nucleoside derivatives 1b-e of adenine, cytosine, 5-methylcytosine, and guanine, co...
Optically pure acyclic nucleoside analogues with a 3(S),5-dihydroxypentyl or 4(R)-methoxy-3(S),5-dih...
The stereoselective synthesis 4′,6′-dually branched carbocyclic nucleosides was accomplished in this...
Novel 1',4'-dimethyl branched carbocyclic nucleosides were synthesized from acetol. The 4&...
with the aim to expand the repertoire of bioactive cyclohexenyl nucleosides, we have herein explored...
Novel methodology for the synthesis of 3\u27-deoxy- and 2\u27 ,3\u27-dideoxy-4\u27 -C-alkyl nucleosi...
A series of doubly flexible nucleoside analogues were designed based on the acyclic sugar scaffold o...
A series of the novel pyrimidine (3-6) and purine (12-15, 18-21) acyclic nucleoside analogues in whi...
Les analogues synthétiques des nucléosides naturels constituant des acides nucléiques occupent une p...
Acyclic nucleosides have been of considerable interest since the approval of aciclovir by the FDA to...
β-Thymidine is a key intermediate in the manufacturing of anti-AIDS agents- AZT and d4 T. A practica...
We describe the synthesis of a variety of lipophilic isosteres of nucleoside triphosphates as potent...
Following our findings on the anti-human immunodeficiency virus (HIV) activity of acyclovir (ACV) ph...
Upon reacting 3',4'-unsaturated cytosine (8 and 9) and adenine nucleosides (13 and 14) with XeF2/BF3...
A new adenine derivative is prepared through the chemistry of nitrosocarbonyl intermediates. The sy...