aClinical and Research Programs in Pediatric Psychopharmacology and Adult ADHD,

D ow nloaded from 2 This study investigated the neural basis of individual variation in emotion regulation, specifically the ability to reappraise negative stimuli so as to down-regulate negative affect. Brain functions in young adults were measured with functional Magnetic Resonance Imaging during three conditions: (1) attending to neutral pictures; (2) attending to negative pictures; and (3) reappraising negative pictures. Resting-state functional connectivity was measured with amygdala and dorsolateral prefrontal cortical (DLPFC) seed regions frequently associated with emotion regulation. Participants reported more negative affect after attending to negative than neutral pictures, and less negative affect following reappraisal. Both attending to negative versus neutral pictures and reappraising versus attending to negative pictures yielded widespread activations that were significantly right-lateralized for attending to negative pictures and left