since the human genome was published has provided more questions than answers. A theme that has emerged from this enormous body of work is that the molecular and functional heterogeneity of cancer makes the study of established cancers complex (Stratton et al., 2009). Although the degree and nature of variegation differs between cancer types, heterogeneity seems to be a fundamental characteristic of neoplasia that is acquired from the earliest stages of tumour development. At the molecular level, first-hit genetic (or epigenetic) alterations are thought to initiate a pre-malignant process by interacting with the existing machinery of th
Aim: Present cancer hypotheses are almost all based on the concept that accumulation of specific dri...
Cancer is a group of heterogeneous diseases that results from the occurrence of genetic alterations ...
Developments in genomic techniques have provided insight into the remarkable genetic complexity of m...
Abstract Analysis of spatial and temporal genetic heterogeneity in human cancers has revealed that s...
Despite the clonal origin of most tumors, their tremendous heterogeneity suggests that cancer progre...
Despite the clonal origin of most tumors, their tremendous heterogeneity suggests that cancer progre...
The extent of tumor heterogeneity is an emerging theme that researchers are only beginning to unders...
Despite the clonal origin of most tumors, their tremendous heterogeneity suggests that cancer progre...
The extent of tumor heterogeneity is an emerging theme that researchers are only beginning to unders...
Cancer - this one word stands for a vast variety of complex diseases. Cancers are named according to...
Human cancers are heterogeneous due to combined effects of genetic instability and selection, where ...
The development of cancer begins with cells transitioning from their multicellular nature to a state...
Increasing evidence supports the existence of intratumor heterogeneity (ITH) in many cancer types, w...
Most lethal solid tumors including hepatocellular carcinoma (HCC) are considered incurable due to ex...
Genetic intratumoural heterogeneity is a natural consequence of imperfect DNA replication. Any two r...
Aim: Present cancer hypotheses are almost all based on the concept that accumulation of specific dri...
Cancer is a group of heterogeneous diseases that results from the occurrence of genetic alterations ...
Developments in genomic techniques have provided insight into the remarkable genetic complexity of m...
Abstract Analysis of spatial and temporal genetic heterogeneity in human cancers has revealed that s...
Despite the clonal origin of most tumors, their tremendous heterogeneity suggests that cancer progre...
Despite the clonal origin of most tumors, their tremendous heterogeneity suggests that cancer progre...
The extent of tumor heterogeneity is an emerging theme that researchers are only beginning to unders...
Despite the clonal origin of most tumors, their tremendous heterogeneity suggests that cancer progre...
The extent of tumor heterogeneity is an emerging theme that researchers are only beginning to unders...
Cancer - this one word stands for a vast variety of complex diseases. Cancers are named according to...
Human cancers are heterogeneous due to combined effects of genetic instability and selection, where ...
The development of cancer begins with cells transitioning from their multicellular nature to a state...
Increasing evidence supports the existence of intratumor heterogeneity (ITH) in many cancer types, w...
Most lethal solid tumors including hepatocellular carcinoma (HCC) are considered incurable due to ex...
Genetic intratumoural heterogeneity is a natural consequence of imperfect DNA replication. Any two r...
Aim: Present cancer hypotheses are almost all based on the concept that accumulation of specific dri...
Cancer is a group of heterogeneous diseases that results from the occurrence of genetic alterations ...
Developments in genomic techniques have provided insight into the remarkable genetic complexity of m...