Journal of Antimicrobial Chemotherapy (1993) 32, 465—472 Therapeutic efficacy of a liposomal formulation of amphotericin B (AmBisome) against murine blastomycosis

The efficacy of a liposomal amphotericin B preparation (AmBisome) and a deoxy-cholate suspension (Fungizone) were compared in a pulmonary model of murine blastomycosis. Male, four-week-old CD-I mice were infected intranasally with 19,400 or 27,450 cfu of viable Blastomyces dermatitidis yeasts and intravenous therapy begun 4 days later. Groups of ten mice were given various dosages of Fungizone or AmBisome or were untreated. All treatments were given 3 times per week for 2 weeks. Deaths were recorded over 49 days and the number of viable yeasts in the lungs of survivors quantitated by viable counting. Therapy wit