Add to ORKGSUMMARY The frequency of chromosome aberrations in the lymphocytes of three established heterozygotes for the Bloom's syndrome gene (ages 67, 57, 46) was compared to that in controls (ages 68, 67, 61, 46, 34). The main part of the study was done on coded slides. No difference was found between the heterozygotes and the control group, except for one control (aged 46) who had a significantly higher number of chromosome aberrations than the others. Individuals with Bloom's syndrome, which is caused by an autosomal recessive gene (bi), have a tendency to chromosomal abnormalities and a predisposition to malignant disease (German, 1969). Whether chromosome breakage and incidence of cancer are also increased in heterozygotes is so far a...
Abstract\ud \ud Introduction\ud Bloom syndrome is a ra...
Bloom syndrome (BS) is an autosomal recessive disorder characterized by increases in the frequency o...
Constitutional aneuploidy is typically caused by a single-event meiotic or early mitotic error. In c...
Background: Bloom′s syndrome, an autosomal recessive inherited disorder, belongs to the group of chr...
Some rare autosomal recessive diseases of humans have been reported to have in common a high frequen...
Bloom syndrome is a rare autosomal recessive syndrome characterized by proportional dwarfism, charac...
Werner’s syndrome (WS) and Bloom’s syndrome (BS) are rare autosomal genetic diseases that predispose...
BS is a rare, autosomal recessive disorder characterized by telangiectasias, photosensitivity, growt...
International audienceBloom syndrome (BS) is a human cancer-prone genetic disorder essentially chara...
Bloom syndrome (BS) is a genetic disorder caused by mutations in the BLM gene, which encodes for a p...
Background: Bloom\u2032s syndrome, an autosomal recessive inherited disorder, belongs to the group o...
is a rare genomic instability syndrome. Despite its autosomal recessive transmission, it shows a mal...
ABSTRACT-Sister chromatid exchange(s) (SCE) per cell and chromosome in five heteroploid cell lines a...
Eighty-three lymphocyte cultures from 67 patients exposed to high therapeutic doses of chemical muta...
Loss of heterozygosity (LOH) is a common genetic alteration in tumors and often extends several mega...
Abstract\ud \ud Introduction\ud Bloom syndrome is a ra...
Bloom syndrome (BS) is an autosomal recessive disorder characterized by increases in the frequency o...
Constitutional aneuploidy is typically caused by a single-event meiotic or early mitotic error. In c...
Background: Bloom′s syndrome, an autosomal recessive inherited disorder, belongs to the group of chr...
Some rare autosomal recessive diseases of humans have been reported to have in common a high frequen...
Bloom syndrome is a rare autosomal recessive syndrome characterized by proportional dwarfism, charac...
Werner’s syndrome (WS) and Bloom’s syndrome (BS) are rare autosomal genetic diseases that predispose...
BS is a rare, autosomal recessive disorder characterized by telangiectasias, photosensitivity, growt...
International audienceBloom syndrome (BS) is a human cancer-prone genetic disorder essentially chara...
Bloom syndrome (BS) is a genetic disorder caused by mutations in the BLM gene, which encodes for a p...
Background: Bloom\u2032s syndrome, an autosomal recessive inherited disorder, belongs to the group o...
is a rare genomic instability syndrome. Despite its autosomal recessive transmission, it shows a mal...
ABSTRACT-Sister chromatid exchange(s) (SCE) per cell and chromosome in five heteroploid cell lines a...
Eighty-three lymphocyte cultures from 67 patients exposed to high therapeutic doses of chemical muta...
Loss of heterozygosity (LOH) is a common genetic alteration in tumors and often extends several mega...
Abstract\ud \ud Introduction\ud Bloom syndrome is a ra...
Bloom syndrome (BS) is an autosomal recessive disorder characterized by increases in the frequency o...
Constitutional aneuploidy is typically caused by a single-event meiotic or early mitotic error. In c...