Human Immunodeficieny Virus Pathogenesis and Prospects for Immune Control in Patients with Established Infection

Infection with human immunodeficiency virus (HIV) results in inevitable progressive deterioration of the immune system in the majority of untreated patients. Prospects for virus eradication are remote, because HIV establishes long-lived reservoirs during the earliest stages of infection that are impervious to available antiviral therapies. Understanding how the immune system copes with this illness and other chronic viral infections is the key to designing future strategies for long-term control of viremia. Valuable insights have been gained from 2 populations in particular: patients with chronic, long-term, nonpro-gressing infections, in whom viremia is controllable in the absence of antiviral medications, and acutely infected patients, in whom the initial HIV-specific immune response might be preserved and augmented by timely intervention. These cases of immune control of HIV provide hope for the development of improved vaccine products that may eventually produce vaccine-induced immunity that will enhance durable control of HIV infection. HIV type 1 (HIV-1), which can be considered to be an infection of the immune system, results in progressive and ultimately pro-found immune suppression in the vast majority of untreated persons. However, persons have now been identified who have been infected for 120 years and remain entirely asymptomatic despite never having been treated with antiviral therapy. Un