SEE PROFILE

year; 2)>1 RI per month involving upper airways from September to April; 3)>3 RI involving lower airways.1 Surely, RRI have a relevant pharmacoeconomic impact and represent a burden for the family. Therefore, this recurrence represents a demanding task for the pediatrician. Many factors may be involved as promoting and/or causing RRI, such as the age (for a relative immaturity of the immune response), the early attending of nursery school, the air and home pollu-tion, the passive smoking, the low socio-economic level, and the atopy.2 In addition, virus infections may increase the probabil-ity of contracting frequent RI because of the high number of circulating viruses and their subtypes.3 Even though most of RRI are sus-tained by viral infection, bacterial over in-fection may appear. In this regard, another relevant issue is the growing rate of anti-biotic resistance occurred in recent years. As most RRI are caused by viral infections, antibiotics may be overused, and antibiotic resistance increase, there is growing inter-est in preventive treatment. In this regard, immunostimulants are widely employed in the common practice. Pidotimod (3-L-py-roglutamyl-L-thiaziolidine-4carboxylic acid