10 authors, including:

Here we present a high-resolution screening (HRS) methodology for postcolumn on-line profiling of metabolites with affinity for the estrogen receptor R (ERR). Tamoxifen, which is metabolized into multiple metabolites, was used as the model compound. Most of the 14 metabolites detected exhibited affinity for the ERR. The HRS methodology shows great potential for metabolite bio-affinity profiling and application in drug discovery and development