Add to ORKGType 1 diabetes mellitus is characterized by a significant deficit in pancreatic b-cell mass, presumably caused by b-cell apo-ptosis. We investigated the incidence of b-cell apoptosis in streptozotocin-treated mice and nonobese diabetic (NOD) mice with 99mTc-annexin A5. Methods: Vehicle-treated mice, strepto-zotocin-treated mice, and NOD mice at the ages of 5, 9, 16, and 20 wk (5–8 mice per group) were injected with 99mTc-annexin A5 and sacrificed 6 h later for autoradiography, and the regional 99mTc-annexin A5 level in the pancreas was eval-uated. Pancreatic islets were identified by insulin immunohis-tochemical staining, and apoptotic cells were determined by terminal deoxynucleotidyl transferase–mediated dUTP nick-end labeling (TUNEL) st...
(A) Representative immunofluorescent images of islets by cleaved caspase-3 (red), β-cell marker insu...
OBJECTIVE: To evaluate the potential therapeutic effect of recombinant human tumor necrosis factor (...
OBJECTIVE: To evaluate the potential therapeutic effect of recombinant human tumor necrosis factor (...
Type 1 diabetes mellitus is characterized by a significant deficit in pancreatic b-cell mass, presum...
The NOD/Lt mouse, a widely used model of human autoimmune IDDM, was used to establish the mode of β-...
Although insulin-dependent diabetes mellitus (IDDM) results from irreversible loss of beta cells, th...
AbstractCrosspresentation of self-antigens by antigen-presenting cells is critical for the induction...
<p><i>A</i>. Nuclear PCNA (green) and insulin (red) staining show same level of proliferating beta c...
<p>Diabetic mice were treated with BPs (30 and 60 mg/kg/day), glyburide (7.2 mg/kg/day), or vehicle ...
<p>A) Enhanced caspase-3 activity is detected in cell extracts of WT than in those of CD44-deficient...
<p>Representative images of pancreas section stained for caspase-3 of control group (A) and HFD-PBS ...
The ability of β cells to endure assaults by various environmental agents, including toxins and viru...
<p><b>(a-p)</b> TUNEL labelling of pancreatic islets exposed to IL-1β, IFN-γ, and TNF-α for 24 hours...
CTLs are important mediators of pancreatic β cell destruction in the nonobese diabetic mouse model o...
Background: Type 1 diabetes mellitus is caused by immune-mediated destruction of pancreatic b-cells ...
(A) Representative immunofluorescent images of islets by cleaved caspase-3 (red), β-cell marker insu...
OBJECTIVE: To evaluate the potential therapeutic effect of recombinant human tumor necrosis factor (...
OBJECTIVE: To evaluate the potential therapeutic effect of recombinant human tumor necrosis factor (...
Type 1 diabetes mellitus is characterized by a significant deficit in pancreatic b-cell mass, presum...
The NOD/Lt mouse, a widely used model of human autoimmune IDDM, was used to establish the mode of β-...
Although insulin-dependent diabetes mellitus (IDDM) results from irreversible loss of beta cells, th...
AbstractCrosspresentation of self-antigens by antigen-presenting cells is critical for the induction...
<p><i>A</i>. Nuclear PCNA (green) and insulin (red) staining show same level of proliferating beta c...
<p>Diabetic mice were treated with BPs (30 and 60 mg/kg/day), glyburide (7.2 mg/kg/day), or vehicle ...
<p>A) Enhanced caspase-3 activity is detected in cell extracts of WT than in those of CD44-deficient...
<p>Representative images of pancreas section stained for caspase-3 of control group (A) and HFD-PBS ...
The ability of β cells to endure assaults by various environmental agents, including toxins and viru...
<p><b>(a-p)</b> TUNEL labelling of pancreatic islets exposed to IL-1β, IFN-γ, and TNF-α for 24 hours...
CTLs are important mediators of pancreatic β cell destruction in the nonobese diabetic mouse model o...
Background: Type 1 diabetes mellitus is caused by immune-mediated destruction of pancreatic b-cells ...
(A) Representative immunofluorescent images of islets by cleaved caspase-3 (red), β-cell marker insu...
OBJECTIVE: To evaluate the potential therapeutic effect of recombinant human tumor necrosis factor (...
OBJECTIVE: To evaluate the potential therapeutic effect of recombinant human tumor necrosis factor (...