Invadolysin acts genetically via the SAGA complex to modulate chromosome structure

Identification of components essential to chromo-some structure and behaviour remains a vibrant area of study. We have previously shown that in-vadolysin is essential in Drosophila, with roles in cell division and cell migration. Mitotic chromosomes are hypercondensed in length, but display an aber-rant fuzzy appearance. We additionally demonstrated that in human cells, invadolysin is localized on the surface of lipid droplets, organelles that store not only triglycerides and sterols but also free histones H2A, H2Av and H2B. Is there a link between the storage of histones in lipid droplets and the aber-rantly structured chromosomes of invadolysin mu-tants? We have identified a genetic interaction be