riot. A rapid comprehensive screening pro- cedure for basic drugs in blood or tissues by gas chromatography

A method is described for the comprehensive screening and analysis of more than 80 basic compounds and metabolites in blood and other biological specimens. The method of Foerster and Mason using 1-chlorobutane as the extracting solvent with gas chromatographic analysis has been further developed and modified so that identification and quantita-tion of as little as 0.1 /Jg/ml of virtually all basic drugs in blood can be accomplished in approximately one and one-half hours. In t roduct ion In the modern toxicology laboratory, it is necessary to de-tect and quantitate a wide spectrum of drugs in biological samples. Numerous drugs are involved in toxic reactions after overdose; for analytical purposes, these can be divided into four groups: volatile substances uch as alcohols, acidi