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1 While incidence of depression tends to decline with age, it often goes untreated in the older adult population (Halverson et al., 2013; Manetti et al., 2014). Factors such as physiological brain changes, chronic diseases, and a large psychosocial burden all put older adults at risk (Rodda, Walker, & Carter, 2011). Furthermore, depression is associated with poor prognosis, often leading to chronic depression, fewer remissions, and other comorbid psychiatric disorders (Manetti et al., 2014). In order to enhance the quality of life in this population, it is important to address the gap in management of depressed older adults. To do this, a holistic, integrative approach is helpful. First, adequate screening is necessary. The U.S. Preventive Services Task Force (USPSTF) recom-mends screening all adults for depression in primary care but only if depression support is available (O’Connor, Whitlock, Beil, & Gaynes, 2009). This means that a primary care provider not only must assess for depression but also must have available resources in support of the individual. The provider must also be vigilant in ruling out other causes of the disease, including central nervous system disor-ders, thyroid disease, substance abuse, infection, sleep disorders, vitamin and electrolyte imbalances, and certain medications (American Psychiatric Association [APA], 2013; Halverson et al., 2013). Next, treatment of depression needs to include appropriate nonpharmacological interventions, as well as appropriate pharmacological interventions, taking into consideration presentation, comorbidi-ties, and polypharmacy. Treatment of depression in this population is often complicated by comorbidi-ties, adverse effects of medications, physical bodily changes, and clinical presentation (Wilson, Mottram, Sivananthan, & Nightingale, 2009). In order to pro-vide holistic care, the health care provider needs to assess the physical, psychosocial, and spiritual eti-ologies of depression and treat each of these factors with both conventional and alternative medicine