Human Pulmonary Alveolar Proteinosis Associated with a Defect in GM-CSF/IL-3/IL-5 Receptor Common b

Pulmonary alveolar proteinosis (PAP) is a heterogenous dis-order of genetic or acquired etiologies. In some cases con-genital PAP is associated with hereditary surfactant protein (SP)-B deficiency. To date, the molecular defect in the ma-jority of patients with PAP has not been identified. In mice, PAP has been generated by targeted deletion of the genes for either the GM-CSF/IL-3/IL-5 receptor common