Inhibition of gastric secretion in man by intestinal fat infusion

The rate of gastric secretion probably depends upon a balance between secretory and inhibitory stimuli; increase of the former or decrease of the latter may lead to excessive acid production (Thompson, 1962). As a possible cause of duodenal ulcer more attention has hitherto been given to increased excitatory than to impaired inhibitory mechanisms. Inhibitory processes originating in the duodenum and small intestine have been shown in dogs. Khizhin, Lobasov, and Sokolov, quoted by Pavlov (1910), demonstrated reduced gastric secretion following the introduction of acid and fat into the duodenum. Since then many workers have confirmed these findings for acid (Sircus, 1958; Andersson