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Geminivirus are a large diverse family of plant viruses that infect a broad variety of plants and cause significant crop losses worldwide. Their genome consists of either one or two single stranded (ss) DNA molecules of approximately equal size, which are encapsidated in geminate virus particles. The only high quality transgene-mediated resistance to geminiviruses is based on induction of sequence-specific degradation of a viral mRNA by a mechanism related to post-transcriptional gene silencing (PTGS), which is similar to RNA interference (RNAi) in other eukaryotes. There are two potential flaws with PTGS-mediated resistance. One is that many if not all plant viruses encode one or more proteins that suppress PTGS. Another is its specificity, since it is dependent on the sequence identity between the transgene and target RNA. Our results also suggest that RNA i technology plays an important role in the silencing of gene against begomovirus