Insulin response to intravenous glucagon in children with familial constitutional short stature

50, 805. Insulin response to intravenous glucagon in children with familial constitutional short stature. An intravenous glucagon test was performed in 8 children with familial constitutional short stature who were also lean. These children were randomly selected from a larger group of children with the same clinical manifes-tation and who had been shown to have a low insuli*response to an oral glucose tolerance test and to an intravenous arginine test, without glucose intolerance. 7 out of 8 children showed a normal insulin response to intravenous glucagon, with a peak level of 53-180 IiU/ml 2 minutes after the injection. It is assumed that these insulin responses represent an intact 'rapid ' pool of insulin within the (-cell, and can explain the absence of glucose intolerance in all the children so far studied. Karp, Laron, and Doron (1973) described a group of 36 children with familial short stature who showed the following common features. Height was below the 3rd centile, skeletal age wa