of America, William Stewart, said in 1967: “The time has come to close the book on infectious diseases. We have basically wiped out infection in the United States. ” This influential com-ment has, however, been contradicted by subsequent events. For example, Jones et al. recently reported that from 1940 to 2004 several hundred new infectious diseases emerged, many of which are zoonotic and bacterial.1 More than half of these new diseases have emerged since the 1970s, with the 1980s being the decade with the most new infections. Clearly, infectious diseases are still an open book. Humans and pathogens share a long co-evolution, and infections have exerted a remarkable influence on the course of historical events and human societies. This has...