Citation and references

Familial association of Von Hippel- free of symptoms. The patient had Lindau complex and 8-,e thalassaemia moderate erythrocytosis, a low mean SIR,-It is well known that the Von corpuscular volume and mean corpus-Hippel-Lindau complex in about 20 % cular haemoglobin, with normal mean of the cases has a familial incidence corpuscular haemoglobin concentration. and that it is inherited.3 Thalassaemia Haemoglobin studies showed a normal is also a genetically determined haema- concentration of A2 haemoglobin and tological disorder characterised by moderate increase of F haemoglobin. underproduction of at least one of the 8-P thalassaemia was suspected and an normal globin peptide chains of haemo- haematologic familiar study confirmed globin. We report the association of the diagnosis. The incidence of both Von Hippel-Lindau complex and 8-,8 diseases in the different members ofVonlssHiplindau compe ad of the family were studied (figure). Thethalassaemiars,sin xofal composed of mother had both S-,8 thalassaemia andaffeihte mbyeorsof whomawere cerebellar haemangioblastoma. TheaffSetedmbyoe or both *diseases. father was free of both diseases. OneIn September 1980, a 27-year-old sister and one brother of the patient man was admitted for treament of a had only S-p thalassaemia, one brother cerebellar haemangioblastoma. His had a retinal angioma and the other mother was successfully treated by us brother had no disease. The only mem-for the same disease 10 years before. ber of the next generation, the son of The tumour was totally removed and the brother with retinal angioma, also the patient discharged 10 days later had a retinal angioma