Relationship With Delayed Cerebral Ischemia and Poor Outcome

Background and Purpose—The ideal timing of coiling or clipping after aneurysmal subarachnoid hemorrhage is unknown. Within the International Subarachnoid Aneurysm Trial we assessed differences in incidence of delayed cerebral ischemia and clinical outcome between different timings of treatment. Methods—The treated 2106 patients randomized to coiling or clipping were divided into 4 categories: treatment 2 days, on days 3 to 4, on days 5 to 10, and 10 days after the hemorrhage. ORs with 95 % CI were calculated with logistic regression analysis for delayed cerebral ischemia, poor outcome at 2 months, and 1 year for the different timing categories, with treatment 2 days as reference. Analyses were performed for all patients, and for coiled and clipped patients separately, and were adjusted for baseline characteristics. Results—Adjusted ORs of delayed cerebral ischemia for treatment on days 5 to 10 were 1.18 (95 % CI, 0.91–1.53) for all patients, 1.68 (95 % CI, 1.17–2.43) after coiling, and 0.79 (95 % CI, 0.54–1.16) after clipping. ORs for poor outcome at 2 months were 1.16 (95 % CI, 0.89–1.50) for treatment (clipping and coiling combined) at 3 to 4 days, 1.39 (95 % CI, 1.08–1.80) for treatment at 5 to 10 days, and 1.84 (95 % CI, 1.36–2.51) for treatment 10 days. ORs for coiled and clipped patients separately were in the same range. Results for outcome at 1 year were similar. Conclusions—Our results support the current practice for early aneurysm treatment in subarachnoid hemorrhage patients. The risk for poor outcome was highest when treatment was performed after day 10; postponing treatment in patients who are eligible for treatment between days 5 to 10 after subarachnoid hemorrhage is not recommended. (Stroke. 2012;43